Dr. Karen Sanguinet
Karen Sanguinet
509-335-3662
karen.sanguinet@wsu.edu
Assistant Professor, Department of Crop and Soil Sciences, 2003 Ph.D. University of California – Berkeley
Research Interests
Research themes in the Sanguinet lab focus on factors that modulate growth and development, particularly in response to the environment. We use physiological, developmental, genetic and genomics approaches to study plant root development and architecture in models such as Arabidopsis thaliana and Brachypodium distachyon as well as crops such as wheat and rice. Through characterization and analysis of mutants and natural accessions, we hope to gain insight into the quantitative and qualitative control of root development. We are also interested in understanding hormonal-cell wall crosstalk and how it constrains morphogenesis. In addition, we are studying genome-wide responses to abiotic stresses such as cold and drought.
Publications
Cong W, Miao Y, Xu L, Zhang Y, Yuan C, Wang J, Zhuang T, Lin X, Jiang L, Wang N, Ma J, Sanguinet KA, Liu B, Rustgi S, Ou X. Transgenerational memory of gene expression changes induced by heavy metal stress in rice (Oryza sativa L.) BMC Plant Biology, 19 (1), 282
Brew-Appiah RAT, Peracchi LM, Sanguinet KA (2019), Never the two shall mix: Robust indel markers to ensure the fidelity of two pivotal and closely-related accessions ofBrachypodium distachyon. Plants 8 (6), 153.
Ma X, Sanguinet KA, Jacoby P. (2019) Performance of direct root-zone deficit irrigation on Vitis vinífera L. cv. ‘Cabernet Sauvignon’ production and water use efficiency in semi-arid southcentral Washington, Agricultural Water Management, 221, 47-57.
Zhang Z, Fu T, Lui Z, Wang X, Xun H, Li G, Ding B, Dong Y, Lin X, Sanguinet KA, Liu B, Wu Y. (2019) Extensive changes in gene expression and alternative splicing due to homeologous exchange in rice segmental allopolyploids, Theoretical and Applied Genetics, 1-14.
Clark I, Jones SS, Reganold JP, Sanguinet KA, Murphy KM (2019) Agronomic performance of perennial grain genotypes in the Palouse region of the Pacific Northwest, USA, Frontiers in Sustainable Food Systems, 3, 39.
Lehman T, Sanguinet KA (2019) Auxin and cell wall crosstalk as revealed by the Arabidopsis thaliana cellulose synthase mutant radially swollen 1, Plant and Cell Physiology, pcz055.
Brew-Appiah RAT, Sanguinet KA (2018) Considerations of AOX functionality revealed by critical motifs and unique domains, International Journal of Molecular Sciences,19(10), 2972
Brew-Appiah, RAT, York ZB, Krishnan V, Roalson, E, Sanguinet KA (2018) Genome-wide identification and analysis of the ALTERNATIVE OXIDASE gene family in diploid and hexaploid wheat, PloS One 13 (8), e0201439
Handakumbura PP, Brow K, Whitney IP, Zhao K, Sanguinet KA, Lee SJ, Olins J, Romero-Gamboa SP, Harrington MJ, Bascom CJ, MacKinnon K, Veling M, Liu L, Lee J, Vogel JP, O’Malley RC, Bezanilla M, Bartley LE, Hazen S (2018) SECONDARY WALL ASSOCIATED MYB1 is a positive regulator of secondary cell wall thickening in Brachypodium distachyon and is not found in the Brassicaceae, The Plant Journal, published online 7/27/2018, https://doi.org/10.1111/tpj.14047
Wu Y, Sun Y, Sun S, Li G, Wang J, Wang B, Lin X, Huang M, Gong Z, Sanguinet KA, Zhang Z, Liu B. (2018) Aneuploidization under segmental allotetraploidy in rice and its phenotypic manifestation, Theoretical and Applied Genetics, 1-13
Martinez S, Thompson A, Wen N, Murphey L, Sanguinet KA, Steber C, Garland-Campbell K (2018) Registration of the Louise/Alpowa Wheat Recombinant Inbred Line Mapping Population, Journal of Plant Registrations doi:10.3198/jpr2017.08.0053crmp
Liu D, Zefroosh N, Hines K, Fang W, Sanguinet KA, Goldner L, Baskin TI (2017) Cellulose synthase motility during primary cell wall synthesis in the grass Brachypodium distachyon, Scientific Reports, 7 (1): 15111
Lehman T, Smertenko A, Sanguinet KA (2017) Auxin, microtubules, and vesicular trafficking: conspirators behind the cell wall. Journal of Experimental Botany, doi: https://doi.org/10.1093/jxb/erx205
Sun, S*, Wu Y*, Lin X, Wang J, Yu J, Sun Y, Miao Y, Li Q, Sanguinet KA‡, Liu B‡ (2017) Hybrid weakness in a rice interspecific hybrid is N-dependent and accompanied by changes in gene expression at both total transcript level and parental allele partitioning, PloS One 12 (3), e0172919. *co-first authors, ‡co-corresponding authors
Itoh J, Sato Y, Sato Y, Hibara K, Shimizu-Sato S, Kobayashi H, Takehisa H, Sanguinet KA, Namiki N, Nagamura Y (2016) Genome-wide analysis of spatio-temporal gene expression patterns during early embryogenesis in rice, Development 143: 1217-1227
(f/k/a Osmont, Karen S) Handakumbura, P.P., D.A. Matos, K.S. Osmont, M.J. Harrington, K. Heo, K. Kafle, S.H. Kim, T.I. Baskin, and S.P. Hazen (2013): Perturbation of Brachypodium distachyon CELLULOSE SYNTHASE A4 or 7 results in abnormal cell walls. BMC Plant Biology, 13: 131.
Sankar, M., K.S. Osmont, J. Rolcik, B. Gujas, D. Tarkowska, M. Strnad, I. Xenarios, and C.S. Hardtke (2011): A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk. Bioinformatics, 27(10): 1404-1412.
Jun, J.H., E. Fiume, A. Roeder, L. Meng, V.K. Sharma, K.S Osmont, C. Baker, C.M. Ha, E.M. Meyerowitz, L.J. Feldman, and J.C. Fletcher (2010): Comprehensive analysis of CLE gene expression and over-expression activity in Arabidopsis. Plant Physiology, 154: 1721-1736.
Scacchi, E.*, K.S. Osmont*, J. Beuchat, P. Salinas, M. Navarrete-Gómez, M. Trigueros, C. Ferrándiz, and C.S. Hardtke (2009): Dynamic, auxin-responsive plasma membrane to nucleus movement of Arabidopsis BRX. Development, Vol. 136: pp. 2059-2067. *-equal contributions
Rodrigues, A., J. Santiago, S. Rubio, A. Saez, K.S. Osmont, J. Gadea, C.S. Hardtke, P.L. Rodriguez (2009): The Short-Rooted Phenotype of the brevis radix Mutant Partly Reflects Root Abscisic Acid Hypersensitivity. Plant Physiology, 149: 1917-28.
Osmont, K.S. and C.S. Hardtke (2008): The topless plant developmental phenotype explained! Genome Biology, 9:219.
Hardtke, C.S., E. Dorcey, K.S. Osmont, and R. Sibout (2007): Phytohormone collaboration: zooming in on auxin-brassinosteroid interactions. Trends in Cell Biology, Vol. 17: pp. 485-492.
Osmont, K.S., R. Sibout, and C.S. Hardtke (2007): Hidden Branches: Developments in Root System Architecture. Annual Review of Plant Biology, Vol. 58: pp. 93-113.
Mouchel, C.F., K.S. Osmont, and C.S. Hardtke (2006): BRX mediates feedback between brassinosteroid levels and auxin signalling in root growth. Nature, Vol. 443: pp. 458-461.
Briggs, G.C., K.S. Osmont, C. Shindo, R. Sibout, and C.S. Hardtke (2006): Unequal genetic redundancies in Arabidopsis – a neglected phenomenon? Trends in Plant Sciences, Vol. 11: pp. 492-498.
Osmont, K.S., N. Sadeghian, and M Freeling (2006): Mosaic analysis of extended auricle1 (eta1) suggests that a two-way signaling pathway is involved in positioning the blade/sheath boundary in Zea mays. Developmental Biology, Vol. 295: pp. 1-12.